Seminars

—Laufer Lecture—

Bringing Materials Fabrication to 21st Century: 3D Nano- and Micro-Architected Materials as Key Enablers for Enhanced Properties, Responsiveness, and Impact Mitigation

J.R. Greer

Ruben F. and Donna Mettler Professor of Materials Science, Mechanics, and Medical Engineering
Applied Physics and Materials Science Department
California Institute of Technology
Pasadena, CA
http://jrgreer.caltech.edu

Creation of reconfigurable and multi-functional materials can be achieved by incorporating architecture into material design. In our research, we design and fabricate three-dimensional (3D) nano-architected materials that can exhibit superior and often tunable mechanical, thermal, photonic, electrochemical, and biochemical properties at extremely low mass densities, which renders them useful and enabling in technological applications. Dominant properties of such meta-materials are driven by their multi-scale hierarchy: from characteristic material microstructure (atoms) to individual constituents (nanometers) to structural components (microns) to overall architectures (millimeters and above).

Our research is focused on the fabrication, synthesis, and characterization of hierarchical materials using additive manufacturing (AM) techniques, as well as on investigating their mechanical, electrochemical, and chemo-mechanical properties as a function of architecture, constituent materials, and microstructural detail. AM represents a set of processes that fabricate complex 3D structures using a layer-by-layer approach, with some advanced methods attaining nanometer resolution and the creation of unique, multifunctional materials and shapes derived from a photoinitiation-based polymerization of custom-synthesized resins and thermal post-processing. A type of additive manufacturing, vat polymerization via hydrogel infusion (HIAM), has allowed for using hydrogels as precursors to produce 3D nano- and micro-architected metals and metal oxides, and exploiting their nano-induced material and structural properties. We describe additive manufacturing via vat polymerization and function-containing chemical synthesis to create 3D nano- and micro-architected metals, ceramics, multifunctional metal oxides, and metal-containing polymer complexes with dynamic bonds, as well as demonstrate their potential in energy storage, microrobotics, and nano- and micro-electronics. I will describe how the choice of architecture, chemical composition, and microstructure can elicit new microstructural orders and induce stimulusresponsive, reconfigurable, and multifunctional response.

Greer’s research focuses on the design, synthesis, fabrication, and characterization of nanoarchitected materials using additive manufacturing (AM) techniques, as well as on investigating their mechanical, electrochemical, and chemo-mechanical properties as a function of architecture, constituent materials, and microstructural detail. We strive to uncover the synergy between the internal atomic- and molecular-level microstructure and the multi-scale external dimensionality, where competing material- (nano) and structure- (architecture) induced size effects drive overall response and govern these properties. Specific topics include applications of 3D nano- and microarchitected materials in devices, energy absorption, ultralightweight energy storage systems, mechanochemistry, reconfigurable and multi-functional materials, and additive manufacturing.

Greer obtained her S.B. in Chemical Engineering with a minor in Advanced Music Performance from MIT in 1997 and a Ph.D. in Materials Science from Stanford, worked at Intel (2000-03) and was a post-doc at PARC (2005-07). Julia joined Caltech in 2007 and currently is a Ruben F. and Donna Mettler Professor of Materials Science, Mechanics, and Medical Engineering at Caltech, the Department Chair of Applied Physics and Materials Science Department, and the Editor in Chief of the Journal of Applied Physics. She was elected to the National Academy of Sciences in 2025 and serves as the Fletcher Foundation Director of the Kavli Nanoscience Institute at Caltech from 2019-2025.

Greer has more than 170 publications, has an h-index of 83, and has delivered over 100 invited lectures, which include 2 TEDx talks, multiple plenary lectures and named seminars at universities: Racheff Distinguished Lecturer at UIUC, Barbara Cooper lecture at Cornell, Israel Pollak Distinguished Lecture Series at Technion, David Pope lecture at Penn, and Thayer Visionaries in Technology at Dartmouth to name a few, the Watson lecture at Caltech, the Gilbreth Lecture at the National Academy of Engineering, the Midwest Mechanics Lecture series, and a “IdeasLab” at the World Economic Forum, and was selected as Alexander M. Cruickshank (AMC) Lecturer at the Gordon Research Conferences (2022).

She was elected as an MRS Fellow (2026), to the National Academy of Sciences (2025), received the Nadai Medal from ASME Materials Division (2024), the Eringer Medal from the Society of Engineering Science (2024), was the inaugural AAAFM-Heeger Award (2019) and was named a Vannevar-Bush Faculty Fellow by the US Department of Defense (2016) and CNN’s 20/20 Visionary (2016). Her work was recognized among Top-10 Breakthrough Technologies by MIT’s Technology Review (2015). Greer was named as one of “100 Most Creative People” by Fast Company and a Young Global Leader by World Economic Forum (2014) and received multiple career awards: Kavli (2014), Nano Letters, SES, and TMS (2013); NASA, ASME (2012), Popular Mechanics Breakthrough Award (2012), DOE (2011), DARPA (2009), and Technology Review’s TR-35, (2008). She is an active member of scientific community through professional societies (MRS, SES, TMS), having organized multiple symposia, been chosen as Conference Chair (MRS, 2021; GRC 2016), served on the Board of Directors for Society of Engineering Science (SES) and on government agency panels: DOE’s Basic Research Needs workshop (2020), National Materials and Manufacturing Board through National Academies (since 2020), and was selected to participate in DoD’s Bush Fellows Research Study Team, BFRST (2020) (see attached photo). Greer is also a concert pianist who performs solo recitals and in chamber groups, with notable performances of “Prejudice and Prodigy” with the Caltech Trio (2019), “Nanomechanics Rap” with MUSE/IQUE (2009), and as a soloist of Brahms Concerto No. 2 with Redwood Symphony (2006) and of Rachmaninoff’s 2^nd piano concerto with the Caltech Orchestra (2025).

Wednesday, August 26, 2026

Reception at 2:30 PM

Seminar at 3:30 PM

Michelson Hall, Room 101 (MCB 101)

 

host: Ronney

Reconstruction of Left Ventricular Pressure Using Cardiovascular Mechanics

Coskun Bilgi

Postdoctoral Researcher
Department of Aerospace & Mechanical Engineering
University of Southern California
Los Angeles, CA

Left ventricular (LV) pressure is a fundamental quantity that provides a direct window into the mechanics and energetic performance of the heart. However, LV pressure is typically measured through invasive cardiac catheterization, limiting its accessibility for routine and longitudinal assessment. This talk will present our efforts to reconstruct the LV pressure waveform noninvasively using a physics-based approach. The cardiac cycle consists of physiologically distinct phases. Rather than describing the entire pressure waveform using a single empirical function, our framework identifies key physiological time instances throughout the cardiac cycle and reconstructs the pressure between them using principles of fluid and solid mechanics. By coupling these phase-specific descriptions through physiological conditions, a continuous LV pressure waveform can be reconstructed and clinically important hemodynamic indices can be estimated without direct ventricular catheterization. We will discuss the development of this framework and its evaluation across both human and preclinical studies. In retrospective human data, reconstructed LV pressure and pressure-derived indices differentiated healthy individuals from patients with heart failure. In preclinical experiments with simultaneous invasive pressure measurements, the method accurately reproduced important hemodynamic metrics across varying cardiac conditions. Together, these studies demonstrate how combining cardiovascular physiology with fundamental mechanics represents a promising step toward the noninvasive diagnosis and monitoring of cardiovascular conditions.

Coskun Bilgi is a postdoctoral researcher in the Department of Aerospace and Mechanical Engineering at the University of Southern California. He earned his Ph.D. in Aerospace and Mechanical Engineering from USC under the supervision of Professor Niema Pahlevan and is continuing his postdoctoral research with him. Prior to USC, he received both his M.S. and B.S. degrees in Mechanical Engineering from Bogazici University. His research focuses on cardiovascular mechanics, with an emphasis on developing physics- and mechanics-based methods for noninvasive assessment of cardiac function and hemodynamics.

Wednesday, September 2, 2026

3:30 PM

Seaver Science Library, Room 202 (SSL 202)

 

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From Surrogates to Solvers: Physics-Embedded Vision Transformers and Foundation Models in Mechanics

Benjamin A. Jasperson

Postdoctoral Scholar
Department of Aerospace & Mechanical Engineering
University of Southern California
Los Angeles, CA

Accurately predicting the behavior of advanced mechanical systems and materials requires capturing complex multiscale phenomena and rare events. While classical numerical methods offer high fidelity, their immense computational costs, especially when bridging disparate scales, often bottleneck the research and design cycle. Artificial intelligence provides a fast, compelling alternative, yet transitioning these tools from black-box data surrogates to rigorous, physics-aware solvers remains a critical challenge.

This talk explores the intersection of solid mechanics and interpretable AI, focusing on strategies to combine the guarantees of traditional solvers with the speed of deep learning. We will examine Vision Transformers (ViTs) as foundational architectures, specifically evaluating their accuracy, numerical stability, and overall performance when applied to continuum mechanics compared to classical methods.

Moving beyond standard surrogate modeling, we will tackle the unique computational challenge of predicting rare events, centered around understanding how unit mechanisms influence crack self-healing in metals. We will discuss how foundation models can map heterogeneous, multiscale materials data into a shared latent space, yielding frameworks that are highly descriptive and predictive of these highly localized phenomena. Finally, we will conclude with a broader vision for the future of AI-embedded computational mechanics.

Benjamin A. Jasperson is a Postdoctoral Scholar at the University of Southern California. His research sits at the intersection of computational mechanics, materials science, and artificial intelligence. Dr. Jasperson brings over a decade of industrial R&D experience to his academic work; he served as a Lead Mechanical Design Engineer on development projects ranging from high-yield neutron sources to medical devices. He holds a Ph.D. in Theoretical & Applied Mechanics from the University of Illinois Urbana-Champaign and is a licensed Professional Engineer.

Wednesday, September 2, 2026

3:30 PM

Seaver Science Library, Room 202 (SSL 202)

 

host: Xu

Homogenizing Origami and Kirigami Metamaterials

Paul Plucinsky

Assistant Professor
Aerospace & Mechanical Engineering Department
University of Southern California
Los Angeles

Shape-morphing finds widespread utility, from the deployment of small stents and large solar sails to actuation and propulsion in soft robots. Kirigami and origami metamaterials, formed by repeating patterns of slits, creases and panels, are a versatile platform for shape-morphing, inspiring the design of many morphing structures and devices. However, it remains a challenge to predict the response of these and other metamaterial systems to a broad range of loads and stimuli, especially under large deformations.

This talk describes general theoretical principles for homogenizing origami and kirigami metamaterials. Our broad goal is to derive, from first principles, an effective mechanical theory for their bulk deformations, valid in the limit of a large number of building blocks. The first part discusses kirigami; the second discusses origami. We present the foundational ingredients of the theory and give numerical demonstrations of its predictive power.

Paul Plucinsky is an Assistant Professor in the USC Department of Aerospace and Mechanical Engineering. His research interests lie at the interface of solid mechanics, materials science and mathematic, where he applies a theory-guided approach to range of topics including the design and modeling of origami and kirigami metamaterials. Prior to joining USC in 2020, Paul was a Postdoctoral Scholar in Aerospace Engineering and Mechanics at the University of Minnesota. He received his Ph.D. in Mechanical Engineering at Caltech in 2017, and a B.S. in Civil Engineering and M.S. in Structural engineering at the University of Michigan in 2011. He received the NSF CAREER Award in 2023.

Wednesday, September 9, 2026

3:30 PM

Seaver Science Library, Room 202 (SSL 202)

 

host: Xu

Engineering Human Health: Biomechanics, Medical Imaging, and Patient-Specific Modeling

Kaveh Laksari

Assistant Professor
Mechanical Engineering Department
University of California, Riverside
Riverside, CA

The human body is a complex mechanical system in which structure, material properties, and physiological function are intimately connected. Yet many of the mechanical processes underlying injury and disease cannot be measured directly in humans. Our laboratory develops engineering approaches that combine biomechanics, medical imaging, computational modeling, biomedical devices, and data-driven methods to uncover these hidden relationships and translate them into tools for understanding and improving human health. In this talk, I will highlight three areas of our research that span scales from tissue mechanics to patient-specific physiology. First, I will discuss our work in traumatic brain injury, where wearable sensors, neuroimaging, and computational models are used to connect head impact biomechanics with changes in brain structure and function. Second, I will describe approaches for characterizing the mechanical behavior of biological materials, including inverse methods that combine experiments and computational mechanics to determine material properties that are difficult to measure directly. Finally, I will present our work in cerebrovascular biomechanics and stroke, where large-scale vascular imaging, automated vessel reconstruction, computational hemodynamics, and machine learning are being integrated to characterize patient-specific cerebrovascular anatomy and function and ultimately improve stroke assessment and outcome prediction.

Together, these studies illustrate a broader research vision: using engineering to infer physiological information that cannot be directly observed, and integrating experiments, imaging, mechanics, and computation toward predictive, patient-specific models of human health.

Kaveh Laksari, Ph.D., is an Associate Professor of Mechanical Engineering at the University of California, Riverside. His research lies at the intersection of biomechanics, medical imaging, computational modeling, and biomedical engineering, with an emphasis on understanding the mechanical mechanisms underlying neurological injury and cerebrovascular disease. His laboratory develops experimental and computational approaches for traumatic brain injury, cerebrovascular biomechanics and stroke, biological material characterization, and patient-specific modeling. Prior to joining UC Riverside, Dr. Laksari was an Assistant Professor at the University of Arizona and a postdoctoral researcher in Bioengineering at Stanford University. He received his PhD in Mechanical Engineering from Temple University. His research has been supported by the National Institutes of Health, National Science Foundation, and American Heart Association.

Wednesday, September 16, 2026

3:30 PM

Seaver Science Library, Room 202 (SSL 202)

 

host: Pahlevan

The Fluid Mechanics of Stroke: unraveling the role of flow and transport in complex cerebrovascular networks

Debanjan Mukherjee

Assistant Professor of Mechanical Engineering
Paul M. Rady Department of Mechanical Engineering
University of Colorado
Boulder, Colorado

Despite many recent medical advances, stroke continues to be a leading global cause of death and disability. The latest American Heart Association statistics reveal that, on average, someone in the United States dies of a stroke every 3 minutes and 14 seconds. As a disease that stems from flow disruption in the brain due to blockage or rupture of an artery in the brain, fluid mechanics plays an intimate role in stroke etiology and treatment. Yet, owing to the inherent complexity of blood flow through complex cerebrovascular network, and associated cerebrovascular physiology, our understanding of the role of fluid mechanics in stroke remains incomplete at best. Here, I will outline a combination of computer simulations, benchtop experiments, and medical image analytics to address this knowledge gap. I will illustrate how we have leveraged this hybrid approach to study mechanisms of ischemic stroke due to embolisms, understand the role of collateral circulation in the brain, and illustrate network level non-linear flow effects that mediate transport of drug such as tissue Plasminogen Activator (tPA) for stroke treatment. Through these examples, we will present a framework for data-integrated digital twins for stroke, and discuss some of the associated challenges and opportunities in developing and translating such digital twins for advancing stroke care.

Debanjan Mukherjee is an Assistant Professor of Mechanical Engineering at the University of Colorado Boulder. He is also a program faculty for the Biomedical Engineering program, and a faculty council member at the BioFrontiers Institute at CU Boulder. He leads an inter-disciplinary flow physics and biofluids research group named FLOWLab. Prof. Mukherjee completed his undergraduate studies at IIT Madras in India, and subsequently his doctoral and post-doctoral training at the University of California, Berkeley. He has received several awards in recognition of his work: including the National Institutes of Health Maximizing Investigators’ Research Award (MIRA); the National Institutes of Health Trailblazer Award; the ORAU Ralph E. Powe Junior Faculty Enhancement Award; the American Heart Association post-doctoral fellowship award; and has been selected as a Research and Innovation Office Faculty Fellow and a Dean’s Excellence Fellow in Generative AI at the University of Colorado Boulder.

Wednesday, September 30, 2026

3:30 PM

Seaver Science Library, Room 202 (SSL 202)

 

host: Garikipati

host: Ronney/Madni

host: Xu

host: Zhao

host: Bermejo-Moreno

host: Xu

host: Sadhal